abstract：:Several randomized trials and meta-analyses have shown that primary angioplasty is superior to thrombolysis in the treatment of ST-segment elevation myocardial infarction (MI) in terms of death, reinfarction, and stroke. However, primary angioplasty should be regarded as the preferred strategy as long as it can not be...

journal_title：Progress in cardiovascular diseases

authors： De Luca G,Suryapranata H,Marino P

更新日期：2008-03-01 00:00:00

abstract：:Stem cells are potential agents for the treatment of myocardial infarcts among other heart diseases. Over the past decade, the scientific community has extensively used a wide variety of cells and examined their capacity to both regenerate the infarcted myocardium and improve functionally the diseased hearts. Some of ...

journal_title：Progress in cardiovascular diseases

authors： Christoforou N,Gearhart JD

更新日期：2007-05-01 00:00:00

abstract：:First isolated in the early 1960s, doxorubicin (DOX) remains among the most effective anticancer drug ever developed. However, this drug has proven to be a double-edged sword because it also causes a cardiomyopathy that leads to a form of congestive heart failure that is usually refractory to common medications. It is...

journal_title：Progress in cardiovascular diseases

authors： Takemura G,Fujiwara H

更新日期：2007-03-01 00:00:00

abstract：:Left ventricular (LV) ejection fraction (EF) and LV end-systolic volumes are important measures of LV global function. However, in many patients with symptoms of heart failure, these measures are within normal limits. This condition is classified as heart failure with normal ejection fraction (HFNEF). Reduced EF and i...

journal_title：Progress in cardiovascular diseases

authors： Edvardsen T,Helle-Valle T,Smiseth OA

更新日期：2006-11-01 00:00:00

abstract：:Studies performed in experimental animal models of hypertension as well as in human hypertension have unequivocally shown that reflex cardiovascular control undergoes profound changes with high blood pressure and participates throughout direct and indirect mechanisms at the development and progression of hypertension-...

journal_title：Progress in cardiovascular diseases

authors： Grassi G,Trevano FQ,Seravalle G,Scopelliti F,Mancia G

更新日期：2006-05-01 00:00:00

abstract：:Acute myocardial infarction is caused by coronary occlusion, and the mainstay of treatment has become reperfusion by either coronary angioplasty with possible stenting or surgical bypass grafting. Unfortunately, reperfusion can seldom be done soon enough to prevent infarction. Thus, the search for effective cardioprot...

journal_title：Progress in cardiovascular diseases

authors： Downey JM,Cohen MV

更新日期：2006-03-01 00:00:00

abstract：:Recent clinical studies performed in human subjects have provided important clues that improved our understanding of the mechanisms of atrial fibrillation (AF) and facilitated development of new treatment strategies. When analyzed together, these studies confirm the complexity and multifactorial nature of AF. Because ...

journal_title：Progress in cardiovascular diseases

authors： Oral H

更新日期：2005-07-01 00:00:00

abstract：:The Ephedra alkaloids have received much press lately secondary to reported adverse events in those using whole extracts as "dietary supplements" for weight loss or athletic performance enhancement. These reports are troubling given the increasing use of these supplements by the general public. We reviewed the availab...

journal_title：Progress in cardiovascular diseases

authors： Andraws R,Chawla P,Brown DL

更新日期：2005-01-01 00:00:00

abstract：:The pharmacologic regulation of lipid metabolism in patients with dyslipidemia is unequivocally associated with significant reductions in risk for cardiovascular morbidity and mortality. A number of therapeutic drug classes have been developed in an effort to ever more precisely and intensively modulate lipid metaboli...

journal_title：Progress in cardiovascular diseases

authors： Davidson MH,Toth PP

更新日期：2004-09-01 00:00:00

abstract：:During the past decade, an overall theme has emerged, validating the exploration of gender-based differences in coronary heart disease (CHD) as a basis for clinical strategies to improve outcomes for women. Underrepresentation of women in most of CHD and lack of gender-specific reporting in many clinical trials contin...

journal_title：Progress in cardiovascular diseases

authors： Wenger NK

更新日期：2003-11-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of morbidity and mortality with annual costs of care exceeding 300 billion US dollars. Although screening tools are advocated for many cancers, the use of subclinical disease tests for cardiovascular disease are considered controversial. Health care payers and many governmen...

journal_title：Progress in cardiovascular diseases

authors： Shaw LJ,Raggi P,Berman DS,Callister TQ

更新日期：2003-09-01 00:00:00

abstract：:The direct medical cost of cardiovascular and circulatory diseases was $151 billion in 1995, approximately 17% of all direct medical care costs in the United States. Incidence and prevalence based estimates indicate that smoking is a major contributing factor for cardiovascular disease and associated costs. Statewide ...

journal_title：Progress in cardiovascular diseases

authors： Lightwood J

更新日期：2003-07-01 00:00:00

abstract：:Radiocontrast media can lead to a reversible form of acute renal failure that begins soon after the contrast dye administration and generally is benign. Contrast media accounts for 10% of all causes of hospital-acquired acute renal failure and represents the third leading cause of in-hospital renal function deteriorat...

journal_title：Progress in cardiovascular diseases

authors： Briguori C,Tavano D,Colombo A

更新日期：2003-05-01 00:00:00

abstract：:The response to injury in the vasculature and the heart is inflammation. Atherosclerosis is often the result of injury followed by inflammation and atherosclerosis. Vascular and myocardial infections from various pathogens, including viruses, bacteria, chlamydia, and other infections result in vascular inflammation an...

journal_title：Progress in cardiovascular diseases

authors： Willerson JT

更新日期：2002-05-01 00:00:00

abstract：:Beta blockers have long been used in patients who have experienced a myocardial infarction. However, many new therapies are available for this patient group, and as a result, the current role of beta blockers may have become uncertain. In this article we address a series of questions related to the important and conti...

journal_title：Progress in cardiovascular diseases

authors： Freemantle N,Urdahl H,Eastaugh J,Hobbs FD

更新日期：2002-01-01 00:00:00

abstract：:Physicians who supervise stress-imaging procedures, whether they be stress nuclear or stress echocardiography tests, are increasingly required to incorporate important principles in the interpretation of the test results. Important guiding principles, common to these tests, are reviewed in this article. The principles...

journal_title：Progress in cardiovascular diseases

authors： Rozanski A

更新日期：2001-01-01 00:00:00

abstract：:The use of noninvasive stress cardiac imaging for stratifying risk in patients with known or suspected coronary artery disease is growing as a tool for identification of the subgroup most likely to benefit from the expense and risk of more invasive procedures, including cardiac catheterization and coronary revasculari...

journal_title：Progress in cardiovascular diseases

authors： Brown KA,Rosman DR,Dave RM

更新日期：2000-11-01 00:00:00

abstract：:Transcranial Doppler ultrasound allows noninvasive monitoring of the large intracranial vessels. Microembolic signals (MES) have been observed under a variety of circumstances, especially in symptomatic carotid stenosis, high-risk cardiac conditions, and surgical procedures (such as carotid endarterectomy and cardiopu...

journal_title：Progress in cardiovascular diseases

authors： Gorman M

更新日期：2000-09-01 00:00:00

abstract：:In contrast to heart transplantation, little effort has been made to estimate the economic implications of mechanical cardiac assistance from either a procedure- or a program-level perspective. With annual direct and indirect expenditures for the treatment of coronary artery disease and congestive heart failure now ex...

journal_title：Progress in cardiovascular diseases

authors： Evans RW

更新日期：2000-07-01 00:00:00

abstract：:Dispersion of ventricular repolarization is a now widely used term describing nonhomogeneous recovery of excitability or heterogeneity of ventricular repolarization. It is usually expressed as the difference or the range of various repolarization measurements obtained from a heart. Experimentally, an increased dispers...

journal_title：Progress in cardiovascular diseases

authors： Franz MR,Zabel M

更新日期：2000-03-01 00:00:00

abstract：:Historically, risk stratification for survivors of acute myocardial infarction (AMI) has centered on 3 principles: assessment of left ventricular function, detection of residual myocardial ischemia, and estimation of the risk for sudden cardiac death. Although these factors still have important prognostic implications...

journal_title：Progress in cardiovascular diseases

authors： Michaels AD,Goldschlager N

更新日期：2000-01-01 00:00:00

abstract：:With the approval of alteplase (tPA) therapy for stroke, it is likely that combination therapy with tPA to restore blood flow, and agents like glutamate receptor antagonists to halt or reverse the cascade of neuronal damage, will dominate the future of stroke care. The authors describe events and potential targets of ...

journal_title：Progress in cardiovascular diseases

authors： Small DL,Morley P,Buchan AM

更新日期：1999-11-01 00:00:00

abstract：:Two central concepts of human hypertensive disease remain poorly understood: (1) elevated blood pressure as merely one component of an underlying systemic condition, characterized by multiple defects in diverse tissues (eg, "Syndrome X"), and (2) the heterogeneity of hypertension, in which different and even opposite ...

journal_title：Progress in cardiovascular diseases

authors： Resnick L

更新日期：1999-07-01 00:00:00

abstract：:Patients with diabetes mellitus have an increased prevalence of hypertension and associated cardiovascular disease (CVD), including coronary and cerebrovascular disease. The risk of an individual of developing CVD is much greater when both diseases coexist and is further magnified by their frequent association with dy...

journal_title：Progress in cardiovascular diseases

authors： Guzmán CB,Sowers JR

更新日期：1999-05-01 00:00:00

abstract：:The repetitive respiratory events that characterize obstructive sleep apnea (OSA) are each followed by abrupt increases in heart rate and in pulmonary and systemic artery pressure and by sudden decreases in right and left ventricular stroke volume. The changes in systemic pressure may be profound, with patients who ar...

journal_title：Progress in cardiovascular diseases

authors： Weiss JW,Launois SH,Anand A,Garpestad E

更新日期：1999-03-01 00:00:00

abstract：:The sympathetic nervous system occupies a prominent role in heart failure both as a marker of severity of disease and also as an important factor in its progression. Beta blocker therapy, once thought heretical in heart failure, has consistently improved cardiac function and slowed progression of disease. Large clinic...

journal_title：Progress in cardiovascular diseases

authors： Carson PE

更新日期：1999-01-01 00:00:00

abstract：:The role of antiarrhythmic agents in the post-MI patients has been investigated for several years. Recently, clinical trials have assessed the effects of amiodarone in the post-MI population. The Basel Antiarrhythmic Study of Infarct Survival (BASIS) trial showed a reduction in total mortality, sudden death, and life-...

journal_title：Progress in cardiovascular diseases

authors： Jafri SM,Borzak S,Goldberger J,Gheorghiade M

更新日期：1998-07-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha), a protein belonging to the family of cytokines, is one of the leading mediators of the immune response to inflammation. Its widespread biological effects are modulated by two circulating binding proteins corresponding to the extracellular domain of the membrane receptors, namel...

journal_title：Progress in cardiovascular diseases

authors： Ceconi C,Curello S,Bachetti T,Corti A,Ferrari R

更新日期：1998-07-01 00:00:00

abstract：:With the exception of the pain of acute aortic dissection, the thoracic aorta is not usually considered as a pain-producing organ. However, nineteenth century clinicians considered the aorta as a source of cardiovascular pain in the presence of autopsy-documented inflammatory aortitis, aortic aneurysms, and arterial h...

journal_title：Progress in cardiovascular diseases

authors： Wooley CF,Sparks EH,Boudoulas H

更新日期：1998-05-01 00:00:00

abstract：:It is being increasingly appreciated that a substantial number of patients with congestive heart failure (CHF) have relatively preserved systolic function. Although these individuals appear to have a somewhat better prognosis than those with low ejection fractions, they experience significant symptoms and frequently r...

journal_title：Progress in cardiovascular diseases

authors： Massie BM,Abdalla I

更新日期：1998-01-01 00:00:00

abstract：:A large number of drug trials for prevention of restenosis have been conducted with many showing little or conflicting benefit. Antiplatelets such as aspirin, ticlopidine and thromboxane A2 receptor inhibitors have not shown a clear benefit. Similarly, antithrombotics, either acting indirectly such as heparin, or as d...

journal_title：Progress in cardiovascular diseases

authors： Lefkovits J,Topol EJ

更新日期：1997-09-01 00:00:00

abstract：:In recent years, a number of peptide and nonpeptide signalling autacoids have been implicated in the regulation of cardiac myocyte growth as well as vasculogenesis and angiogenesis, and in the function of cardiac muscle following development. In this review, we first examine the evidence for a role for specific cytoki...

journal_title：Progress in cardiovascular diseases

authors： Balligand JL,Kelly RA,Smith TW

更新日期：1997-01-01 00:00:00

abstract：:Stents or endoprostheses have evolved since their introduction. Initially used only in the vascular system, the use of stents has expanded to use in the biliary, urinary, and gastrointestinal tracts and in the tracheo-bronchial tree. Current use of stents includes treatment of both benign and malignant conditions, wit...

journal_title：Progress in cardiovascular diseases

authors： Vanderburgh L,Ho CS

更新日期：1996-09-01 00:00:00

abstract：:Because not all laboratories use the monitoring and stimulation protocols used in the Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) trial, we reanalyzed the ESVEM patients' data using alternative, commonly used Holter monitor (HM) and programmed stimulation efficacy criteria to determine if d...

journal_title：Progress in cardiovascular diseases

authors： Reiffel JA,Reiter MJ,Freedman RA,Mann D,Huang SK,Hahn E,Hartz V,Mason J,ESVEM Investigators.

更新日期：1996-03-01 00:00:00

abstract：:The relationship between thyroid disease states and cardiovascular hemodynamics is well recognized. Although the long-term effects of thyroid hormone are thought to result from changes in myocardial gene expression, attention has recently focused on acute, non-nuclear-mediated actions of L-triidothyronine (T3), the bi...

journal_title：Progress in cardiovascular diseases

authors： Klemperer JD,Ojamaa K,Klein I

更新日期：1996-01-01 00:00:00

abstract：:The decrease in ovarian function culminating in the last menstrual period, the menopause, in women in their forties and fifties takes place over a period of 3 to 5 years. There are several immediate clinical consequences of the menopause that are easy to detect and treat, usually with hormone replacement. In contrast,...

journal_title：Progress in cardiovascular diseases

authors： Kleerekoper M,Sullivan JM

更新日期：1995-11-01 00:00:00

abstract：:The role of metabolic processes in the control of the normal circulation will be discussed with particular emphasis on how metabolic events, particularly those that occur with the performance of exercise, result in production of vasoactive substances and sympathetic activation. Heart failure patients will have altered...

journal_title：Progress in cardiovascular diseases

authors： Delehanty JM,Liang CS

更新日期：1995-07-01 00:00:00

abstract：:Patients at a low probability of acute cardiac pathology constitute a considerable proportion in many coronary care units (CCUs), such that physicians should consider more effective alternatives than CCU admission "to rule out myocardial infarction." In this article, strategies to increase the efficiency of managing p...

journal_title：Progress in cardiovascular diseases

authors： Grijseels EW,Deckers JW,Hoes AW,Hartman JA,van der Does E,Simoons ML

更新日期：1995-05-01 00:00:00

abstract：:Our review of the current literature and experience in caring for pacemaker patients suggests that a consideration of hemodynamics is a logical way to approach pacemaker selection and programming. Multiple clinical factors enter into the selection of a pacemaker or pacemaker programming settings in each case. It appea...

journal_title：Progress in cardiovascular diseases

authors： Buckingham TA,Janosik DL,Pearson AC

更新日期：1992-03-01 00:00:00

abstract：:Since the early 1900s, coffee has been implicated as having adverse effects on human health. Recent attention has focused on coffee's relation to CHD, but because of conflicting results of epidemiologic studies on coffee and CHD mortality, attention has turned to the effects of coffee and caffeine on individual CHD ri...

journal_title：Progress in cardiovascular diseases

authors： Rosmarin PC

更新日期：1989-11-01 00:00:00